US president launches ‘Genesis Mission’ to accelerate AI in science

On November 24, 2025, U.S. President Donald Trump signed an executive order establishing the “Genesis Mission.” According to the White House, this national initiative aims to use artificial intelligence to speed up scientific discovery and maintain America’s technological leadership. The project has been compared in ambition to the Manhattan Project of World War II.

The order directs the Department of Energy (DOE) to build and operate the “American Science and Security Platform.” This platform will integrate the nation’s high-performance computing resources, including supercomputers at 17 national laboratories, with vast federal scientific datasets collected over decades. The goal, as stated in the order, is to train advanced “foundation models” and create “AI agents” capable of testing hypotheses and automating research workflows.

Goals and Collaborators

The initiative will focus on several priority areas of national importance. These include:

  • Biotechnology
  • Critical materials
  • Nuclear fission and fusion energy
  • Quantum information science
  • Semiconductors and microelectronics

The White House and the DOE have announced a broad coalition of collaborators from the private sector. The list includes major AI and cloud computing firms like OpenAI for Government, Anthropic, Google, Microsoft, and NVIDIA, as well as industrial companies such as Collins Aerospace and Micron. The executive order instructs the DOE to create standardized partnership agreements to govern data sharing, intellectual property, and commercialization.

Funding Questions and Community Concerns

While the mission’s scope is extensive, the executive order does not specify a budget or request new funding. News outlets like Reuters and VentureBeat have noted this omission, pointing out that financing will depend on future appropriations.

This has led to questions within the AI community. VentureBeat reported on concerns that the initiative could function as an indirect subsidy for large AI companies facing high computing costs. The order establishes a framework for private companies to potentially access federal computing resources and data, but it does not guarantee access or specify pricing. The initiative also emphasizes controlled access based on national security protocols, and it makes no mention of supporting open-source AI development.

The Secretary of Energy is responsible for implementing the mission, with deadlines set for key milestones over the next nine months. The Assistant to the President for Science and Technology will provide overall leadership and coordinate efforts across government agencies. The order mandates annual reports to the President on the project’s progress.

Sources: The White House, VentureBeat, Reuters

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